Interleukin-2 in combination with interferon-alpha in disseminated malignant melanoma and advanced renal cell carcinoma. A phase I/II study.

@article{Bergmann1990Interleukin2IC,
  title={Interleukin-2 in combination with interferon-alpha in disseminated malignant melanoma and advanced renal cell carcinoma. A phase I/II study.},
  author={Lothar Bergmann and Eckhart Weidmann and Paris Sophokles Mitrou and Ulf Runne and Ulrich Keilholz and Hans Helge Bartsch and Chris R. Franks},
  journal={Onkologie},
  year={1990},
  volume={13 2},
  pages={137-40}
}
In vitro, the combination of interleukin-2 (Il-2) with interferon-alpha (IFN-alpha) seems to act synergistically on the generation of lymphokine activated killer (LAK) cells. Due to this fact two clinical trials with the combination of Il-2 and IFN-alpha were initiated in malignant melanoma (MM) and renal cell cancer (RCC). Patients with disseminated MM were treated by a sequential application of 10 x 10(6) U/m2 rIFN-alpha 2b s.c. on days 1-7 followed by continuous intravenous infusion of 3 x… CONTINUE READING
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