Interleukin-2 gene-transduced human leukemic cells induce major histocompatibility complex-restricted and -unrestricted anti-leukemic effectors in mixed lymphocyte-tumor cultures

@article{Cignetti2000Interleukin2GH,
  title={Interleukin-2 gene-transduced human leukemic cells induce major histocompatibility complex-restricted and -unrestricted anti-leukemic effectors in mixed lymphocyte-tumor cultures},
  author={Alessandro Cignetti and Anna Rita Guarini and Anna Gillio Tos and Gigliola Reato and Robert Fo{\`a}},
  journal={Cancer Gene Therapy},
  year={2000},
  volume={7},
  pages={167-176}
}
To explore the feasibility of designing vaccination protocols in acute leukemia patients with cytokine gene-transduced leukemic cells, we studied in vitro the growth potential of human leukemic cells transduced with the interleukin-2 (IL-2), IL-7, or IL-7 plus IL-2 genes, as well as the capacity of generating both autologous and allogeneic cytotoxic… CONTINUE READING