Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

@article{Nagy2002Interleukin2FC,
  title={Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.},
  author={Zsuzsanna S. Nagy and Yuling Wang and Rebecca A. Erwin-Cohen and J{\'a}nos Aradi and Brett A Monia and Li Hua O. Wang and Stanislaw M. Stepkowski and Hallgeir Rui and Robert A. Kirken},
  journal={Journal of leukocyte biology},
  year={2002},
  volume={72 4},
  pages={819-28}
}
Signal transducer and activator of transcription (Stat)5a and Stat5b are critical for normal immune function. Progression of T cells through G(1)-S phase of cell cycle requires T cell receptor (TCR)- and/or cytokine-inducible tyrosine phosphorylation of Stat5a/b. Stat5a/b may also, in a cell-dependent manner, be constitutively or cytokine-inducibly phosphorylated on a Pro-Ser-Pro (PSP) motif located within the transcriptional activation domain. Phosphorylation of the PSP motif is needed for… CONTINUE READING