Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome.

@article{Rook1983Interleukin2ET,
  title={Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome.},
  author={Alain H. Rook and Henry Masur and H. Clifford Lane and W R Frederick and Tadashi Kasahara and Abe M. Macher and Julie Y. Djeu and Jody F. Manischewitz and L. A. Jackson and Anthony S. Fauci and Gerald V. Quinnan},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={72 1},
  pages={398-403}
}
The recently described acquired immune deficiency syndrome (AIDS) is characterized by the occurrence of severe opportunistic infections and an aggressive form of Kaposi's sarcoma. A variety of profound defects in cell-mediated immunity have been reported in association with the AIDS, including deficiencies in natural killer (NK) cell activity and cytomegalovirus (CMV)-specific cytotoxicity. In the present study, the in vitro effects of interleukin-2 (IL-2) and interferon beta (IFN Beta) on… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 11 references

Correlation of clinical outcome of cytomegalovirus infection and immunosuppression with virus specific cytotoxic lymphocyte responses in renal transplant recipients

  • S. Plotkin, R. B. Herberman
  • Pathogenesis and Prevention of Human CMV Disease…
  • 1983

Lymphokine - activated killer cell phenomenon . II . The precursor phenotype is serologically distinct from peripheral T lymphocytes , memory CTL , and NK cells

  • D. Henriksen, J. Vilcek
  • J . Exp . Med .
  • 1983

Natural killer cell activity and interferon release predict survival from viral infection in bone marrow transplant recipients

  • W. E. Biddison
  • 1983

The role of the human major histocompatibility complex in cytotoxic T - cell responses to virus - infected cells

  • W. R. Benjamin, M. L. Hilfiker, M. Howard, W. L. Farrar, J. Fuller-Farrar
  • J . Clin . Immunol .
  • 1982

An outbreak of community - acquired Pneumocystis carinni pneumonia : initial manifestation of cellular immune dysfunction

  • M. S. Gottlieb, R. Schroff, H. M. Shanker, P. T. Fan, R. A. Wolf, A. Saxon
  • N . Engl . J . Med .
  • 1981

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