Interleukin-2-deficient mice develop colitis in the absence of CD28 costimulation.

  title={Interleukin-2-deficient mice develop colitis in the absence of CD28 costimulation.},
  author={David L. Boone and Themistocles Dassopoulos and James P. Lodolce and Sophia Chai and Marcia Chien and Averil Ma},
  journal={Inflammatory bowel diseases},
  volume={8 1},
The intestinal lamina propria contains lymphocytes that are chronically activated by exposure to luminal antigens. Dysregulation of these cells is thought to be central to the pathogenesis of bowel inflammation in experimental models of inflammatory bowel disease. CD28 signals on peripheral T cells provide important costimulatory signals that enhance T-cell proliferation and activation responses to antigens. However, the role of CD28 signals in lamina propria T cells or models of inflammatory… CONTINUE READING