Interleukin-2 apparently upregulates its receptor and induces proliferation of various resting mononuclear leukocytes in the absence of antigen.


We demonstrate that exposure to highly purified recombinant interleukin 2 (rIL-2) in the absence of known antigenic stimulation induces/increases the expression of two activation-associated proteins, the interleukin 2 receptor (IL-2R) and 4F2 on "resting" peripheral blood mononuclear cells (PBMC); subsequently, these cells enter the S phase of the cell… (More)


  • Presentations referencing similar topics