Interleukin-2 and interleukin-4 increase the survival of retinal ganglion cells in culture.

@article{ShollFranco2001Interleukin2AI,
  title={Interleukin-2 and interleukin-4 increase the survival of retinal ganglion cells in culture.},
  author={Alfred Sholl-Franco and K G Figueiredo and Elizabeth Giestal de Araujo},
  journal={Neuroreport},
  year={2001},
  volume={12 1},
  pages={109-12}
}
Natural cell death is a degenerative phenomenon observed during the normal development of the nervous system. The neuroprotective effects of cytokines produced by neuronal, glial or infiltrating cells on neurons have been extensively studied. In this work we studied the role of interleukin (IL)-2 and IL-4 on the survival of retinal ganglion cells (RGC) after 48 h in culture. Our results demonstrate that the effect of both ILs was dose-dependent and the treatment with either IL-2 (50 U/ml) or IL… CONTINUE READING

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