Interleukin-2 and -6 induce behavioral-activating effects in mice.

  title={Interleukin-2 and -6 induce behavioral-activating effects in mice.},
  author={Steven Zalcman and Lynnette Murray and D G Dyck and Arnold H. Greenberg and Dwight M. Nance},
  journal={Brain research},
  volume={811 1-2},
Interleukin (IL)-1, IL-2 and IL-6 influence central monoamine activity in a cytokine-specific manner. We demonstrated that whereas IL-2 increased hypothalamic and hippocampal norepinephrine (NE) utilization, and DA turnover in the prefrontal cortex, IL-6 induced profound elevations of serotonin (5-HT) and mesocortical dopamine (DA) activity in the hippocampus and prefrontal cortex [S. Zalcman, J.M. Green-Johnson, L. Murray, D.M. Nance, D.G. Dyck, H. Anisman, A. H. Greenberg, Cytokine-specific… CONTINUE READING
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