Interleukin-2 administration alters the CD4+FOXP3+ T-cell pool and tumor trafficking in patients with ovarian carcinoma.

@article{Wei2007Interleukin2AA,
  title={Interleukin-2 administration alters the CD4+FOXP3+ T-cell pool and tumor trafficking in patients with ovarian carcinoma.},
  author={Shuang Wei and Ilona Kryczek and Robert Edwards and Linhua Zou and Wojciech Szeliga and Mousumi Banerjee and Marilyn R. Cost and Pui leng Cheng and Alfred E. Chang and Bruce R Redman and Ronald B. Herberman and Weiping Zou},
  journal={Cancer research},
  year={2007},
  volume={67 15},
  pages={7487-94}
}
Interleukin (IL)-2 is used in the immunotherapy of patients with certain cancer and HIV infection. IL-2 treatment reliably results in 16% to 20% objective clinical response rate in cancer patients, with significant durability of responses in selected patients. However, the mechanisms of therapeutic activity in responding versus nonresponding patients remain poorly understood. CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells contribute to immunosuppressive networks in human tumors. We treated 31… CONTINUE READING

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