Interleukin-1beta up-regulates nitrite production: effects on ovarian function.

  title={Interleukin-1beta up-regulates nitrite production: effects on ovarian function.},
  author={A Rodr{\'i}guez Est{\'e}vez and Mariana Farina and Ana Mar{\'i}a Franchi and Candace S. Johnson and Margarita Vega and Alicia Beatriz Motta},
  journal={Nitric oxide : biology and chemistry},
  volume={10 2},
We have previously reported that Interleukin-1beta (IL-1beta) affects ovarian function in the rat, modulating prostaglandin and progesterone (P) production. As IL-1beta effects were associated to nitric oxide (NO) synthesis, in the present work we have further examined the role of ovarian NOS-system, in IL-1beta antisteroidogenic action. Mid-luteal explants from rats were incubated for 4 h in the presence of IL-1beta (1-35 ng/ml)-alone or in combination with NOS-inhibitors-and then assayed for… CONTINUE READING