Interleukin-1beta regulates pituitary follistatin and inhibin/activin betaB mRNA levels and attenuates FSH secretion in response to activin-A.

@article{Bilezikjian1998Interleukin1betaRP,
  title={Interleukin-1beta regulates pituitary follistatin and inhibin/activin betaB mRNA levels and attenuates FSH secretion in response to activin-A.},
  author={Louise M. Bilezikjian and Andrew V. Turnbull and Anne Z. Corrigan and Amy L. Blount and Catherine L. Rivier and Wylie W. Vale},
  journal={Endocrinology},
  year={1998},
  volume={139 7},
  pages={3361-4}
}
Activins and follistatins regulate all levels of the reproductive axis, including the pituitary where they stimulate and inhibit FSH production, respectively. Gonadotropes are known to express inhibin/activin betaB and activin-B (betaBbetaB) functions as an autocrine modulator of FSH production. By contrast, the mRNA for the activin-binding protein, follistatin, is present in most pituitary cells and folliculo-stellate cells may be the major source of the protein secreted by the anterior… CONTINUE READING