Interleukin-1beta promotes repair of the CNS.

  title={Interleukin-1beta promotes repair of the CNS.},
  author={Jeffrey L. Mason and Kinuko Suzuki and David D. Chaplin and Glenn K. Matsushima},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={21 18},
Interleukin-1beta (IL-1beta) is a proinflammatory cytokine associated with the pathophysiology of demyelinating disorders such as multiple sclerosis and viral infections of the CNS. However, we demonstrate here that IL-1beta appears to promote remyelination in the adult CNS. In IL-1beta(-/-) mice, acute demyelination progressed similarly to wild-type mice and showed parallel mature oligodendrocyte depletion, microglia-macrophage accumulation, and the appearance of oligodendrocyte precursors. In… CONTINUE READING
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