Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guérin in the rat hippocampus.

@article{Palin2004Interleukin1betaMT,
  title={Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Gu{\'e}rin in the rat hippocampus.},
  author={Karine Palin and R. -M. Bluthe and Dani{\'e}le Verrier and Viviane Tridon and Robert Dantzer and Jacques Lestage},
  journal={Brain, behavior, and immunity},
  year={2004},
  volume={18 3},
  pages={223-30}
}
Interleukin-1beta (IL-1beta) plays a major role in the initiation and exacerbation of brain inflammation, and its action is limited by the natural antagonist of IL-1 receptors, IL-1Ra. The aim of the present study was to test the hypothesis that IL-1beta mediates the functional consequences of inflammation during the course of delayed-type hypersensitivity response to bacillus Calmette-Guérin (BCG) in the hippocampus of Lewis rats. Animals were primed with an injection of BCG in the right… CONTINUE READING
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