Interleukin-1beta mediates ischemic injury in the rat retina.

  title={Interleukin-1beta mediates ischemic injury in the rat retina.},
  author={Shinji Yoneda and Hidenobu Tanihara and Noriaki Kido and Y. Hasegawa Honda and Wakana Goto and Hideaki Hara and Nobuaki Miyawaki},
  journal={Experimental eye research},
  volume={73 5},
Two types of experiment were performed to examine the role of interleukin-1beta in ischemia-induced damage in the rat retina. In the in vivo study, enzyme-linked immunosorbent assay was used to investigate the expression of immunoreactive interleukin-1beta in the rat retina following a hypertension-induced ischemia/reperfusion, while the effect of a recombinant human interleukin-1 receptor antagonist or an anti-interleukin-1beta neutralizing antibody on the ischemia-induced damage was examined… CONTINUE READING


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