Interleukin-1beta induces in vivo tolerance to lipopolysaccharide in mice.

  title={Interleukin-1beta induces in vivo tolerance to lipopolysaccharide in mice.},
  author={Fernanda Alves-Rosa and Marisa Vulcano and Macarena Beigier-Bompadre and Gabriela Cristina Fern{\'a}ndez and Marina Sandra Palermo and Mart{\'i}n Amadeo Isturiz},
  journal={Clinical and experimental immunology},
  volume={128 2},
Endotoxin or lipopolysaccharide (LPS) tolerance may be partially due to the secretion of potent anti-inflammatory cytokines following severe Gram-negative infections, or by low doses of LPS. In this work, we describe the effects of interleukin-1 (IL-1) and tumour necrosis factor alpha (TNF-), two early cytokines secreted after LPS exposure, in the induction of LPS tolerance. Our results demonstrate that mice treated with three daily doses of 100 ng of IL-1 were tolerant to LPS-induced shock… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 44 references

Mechanism of endotoxin

F Randow, U Syrbe, C Meisel
desensi© 2002 Blackwell Science Ltd, Clinical and Experimental Immunology, • 2002

Role of the hypothalamuspituitaryadrenal axis in the regulation of TNF production in mice

G Fantuzzi, E DiSanto, S Sacco, F Benigni, P Ghezzi
Genes Dev • 1999

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