Interleukin-1beta induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle.

@article{Tribe2003Interleukin1betaIC,
  title={Interleukin-1beta induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle.},
  author={Rachel M Tribe and Patrick Moriarty and Annette Dalrymple and Abdul A Hassoni and Lucilla Poston},
  journal={Biology of reproduction},
  year={2003},
  volume={68 5},
  pages={1842-9}
}
We have previously reported increased protein expression of sarcoplasmic reticulum calcium ATPase (SERCA) 2b in myometrium from women in labor at term, but the stimulus for this change is unknown. Proinflammatory cytokines have been implicated in the cascade of events leading to preterm and term labor, and we hypothesize that interleukin (IL)-1beta may induce changes in key calcium homeostatic mechanisms and, in turn, augment myometrial contractility before labor. The aim of the present study… CONTINUE READING

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