Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis.

@article{John2004Interleukin1betaIA,
  title={Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis.},
  author={Gareth R. John and Lanfen Chen and Mark A Rivieccio and Carmen V. Melendez-Vasquez and Adam Hartley and Celia F. Brosnan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 11},
  pages={2837-45}
}
The cytokine interleukin-1beta (IL-1beta) is critical to the formation of an astrocytic scar after CNS injury, but the mechanisms by which it induces a reactive phenotype remain unresolved. Here, we show that IL-1beta regulates the phenotype of astrocytes via deactivation of the Rho GTPase-Rho kinase (ROCK) pathway, which governs cellular morphology and migration via effects on F-actin and its interactions with focal adhesions, nonmuscle myosin, and microvillar adapter proteins of the ezrin… CONTINUE READING

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