Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi.

  title={Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi.},
  author={E Barchasz and Emmanuel Naline and Mathi{\'e}u Molimard and Joelle Moreau and Odette Georges and Xavier Emonds-Alt and Charles Advenier},
  journal={European journal of pharmacology},
  volume={379 1},
Interleukin-1beta has been reported to induce airway hyperresponsiveness in several animal models. In this study, we have investigated whether interleukin-1beta was able to potentiate the contractions of human isolated small bronchi (internal diameter < or = 1 mm) provoked by a specific tachykinin NK1 receptor agonist, [Sar9,Met(O2)11]substance P. Pre… CONTINUE READING