Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?

@article{Goehler1999Interleukin1betaII,
  title={Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?},
  author={Lisa Elane Goehler and R. P. A. Gaykema and Kien T. Nguyen and Jong Eun Lee and Fred J. H. Tilders and Steven F. Maier and Linda R. Watkins},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 7},
  pages={2799-806}
}
Intraperitoneal administration of the cytokine interleukin-1beta (IL-1beta) induces brain-mediated sickness symptoms that can be blocked by subdiaphragmatic vagotomy. Intraperitoneal IL-1beta also induces expression of the activation marker c-fos in vagal primary afferent neurons, suggesting that IL-1beta is a key component of vagally mediated immune-to-brain communication. The cellular sources of IL-1beta activating the vagus are unknown, but may reside in either blood or in the vagus nerve… CONTINUE READING

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