Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes.

Abstract

OBJECTIVE To assess the variations of galactose-beta-1,3-glucuronosyltransferase I (GlcAT-I) expression related to the decrease in proteoglycan synthesis mediated by interleukin-1beta (IL-1beta) in rat chondrocytes, and to evaluate the influence of glucosamine on the effects elicited by this proinflammatory cytokine. METHODS Rat articular chondrocytes in… (More)

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@article{Gouze2001Interleukin1betaDT, title={Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes.}, author={J N Gouze and Karim Bordji and Sandrine Gulberti and Bernard Terlain and P. Netter and Jacques Magdalou and Sylvie Fournel-Gigleux and Mohamed Ouzzine}, journal={Arthritis and rheumatism}, year={2001}, volume={44 2}, pages={351-60} }