Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

@article{Clausen2008Interleukin1betaAT,
  title={Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice},
  author={Bettina Hjelm Clausen and Kate Lykke Lambertsen and Alicia Anne Babcock and Thomas Helles\oe Holm and Frederik Dagnaes-hansen and Bente Finsen},
  journal={Journal of Neuroinflammation},
  year={2008},
  volume={5},
  pages={46 - 46}
}
Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are expressed by microglia and infiltrating macrophages following ischemic stroke. Whereas IL-1β is primarily neurotoxic in ischemic stroke, TNF-α may have neurotoxic and/or neuroprotective effects. We investigated whether IL-1β and TNF-α are synthesized by overlapping or segregated populations of cells after ischemic stroke in mice. We used flow cytometry and immunohistochemistry to examine cellular co-expression of IL-1β and TNF-α at… CONTINUE READING
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