Interleukin-1beta and rhinovirus sensitize adenylyl cyclase in human airway smooth-muscle cells.

@article{Billington2001Interleukin1betaAR,
  title={Interleukin-1beta and rhinovirus sensitize adenylyl cyclase in human airway smooth-muscle cells.},
  author={Charlotte K. Billington and Rodolfo M Pascual and Michael L. Hawkins and Raymond B. Penn and Ian P Hall},
  journal={American journal of respiratory cell and molecular biology},
  year={2001},
  volume={24 5},
  pages={633-9}
}
Rhinovirus (RV) is a major cause of wheezing in asthmatics and has been reported to cause beta2 adrenergic receptor hyporesponsiveness in human airway smooth muscle (HASM) via cellular secretion of interleukin (IL)-1beta. We studied the effects of IL-1beta and RV on cyclic adenosine monophosphate (cAMP) production in HASM cells. Chronic incubation with IL-1beta or RV caused a significant increase (approximately 3- and approximately 2-fold, respectively) in forskolin (FSK)-stimulated cAMP… CONTINUE READING

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