Interleukin-1beta administered intracerebroventricularly stimulates the release of noradrenaline in the hypothalamic paraventricular nucleus via prostaglandin in the rat.

@article{Tsumori1998Interleukin1betaAI,
  title={Interleukin-1beta administered intracerebroventricularly stimulates the release of noradrenaline in the hypothalamic paraventricular nucleus via prostaglandin in the rat.},
  author={Chiaki Tsumori and Tamotsu Shibasaki and Masanaka Hotta and Kyousuke Takeuchi and Naoko Yamauchi and Toshihiro Imaki and Ichiji Wakabayashi and Hiroshi Demura},
  journal={Endocrine journal},
  year={1998},
  volume={45 1},
  pages={
          127-30
        }
}
We evaluated the effect of intracerebroventricular (i.c.v.) administration of interleukin (IL)-1beta on the rectal temperature and the release of noradrenaline (NA) in the hypothalamic paraventricular nucleus (PVN) of the rat. IL-1beta increased rectal temperature at doses ranging from 300 pg to 300 ng, whereas it, at doses ranging from 3 ng to 300 ng, significantly stimulated the release of NA in the PVN measured by intracerebral microdialysis. The stimulatory effect of IL-1beta on the release… CONTINUE READING