Interleukin-1alpha regulates substance P expression and release in adult sensory neurons.

@article{Skoff2009Interleukin1alphaRS,
  title={Interleukin-1alpha regulates substance P expression and release in adult sensory neurons.},
  author={Anne M. Skoff and Changqing Zhao and Joshua E. Adler},
  journal={Experimental neurology},
  year={2009},
  volume={217 2},
  pages={395-400}
}
Nerve injury frequently results in development of chronic, dysesthetic pain and allodynia (painful sensation in response to benign stimulation). Following nerve injury, spinal cord glia become activated and secrete a number of inflammatory cytokines, including interleukin-1 (IL-1), which exists as two genetically distinct proteins, IL-1alpha and IL-1beta. To investigate whether neuropeptide expression could be altered by exposure to these cytokines, dorsal root neurons from mature rats were… CONTINUE READING

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