Interleukin-1alpha has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model

@article{Mika2008Interleukin1alphaHA,
  title={Interleukin-1alpha has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model},
  author={Joanna Mika and Michal Korostynski and Dorota Kaminska and Agnieszka Wawrzczak-Bargiela and Barbara Przewlocka},
  journal={PAIN},
  year={2008},
  volume={138},
  pages={587-597}
}
Nerve injury and the consequent release of interleukins (ILs) are processes implicated in pain transmission. To study the potential role of IL-1 in the pathogenesis of allodynia and hyperalgesia, IL-1alpha and comparative IL-1beta, IL-6, and IL-10 mRNA levels were quantified using competitive RT-PCR of the lumbar spinal cord and dorsal root ganglia (DRG; L5-L6) three and seven days after chronic constriction injury (CCI) in rats. Microglial and astroglial activation in the ipsilateral spinal… CONTINUE READING
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