Interleukin-1alpha and -1beta promoter polymorphisms in Taiwanese patients with dementia.

  title={Interleukin-1alpha and -1beta promoter polymorphisms in Taiwanese patients with dementia.},
  author={H K Wang and Wen-Chuin Hsu and Hon Chung Fung and Jun-Cheng Lin and Hai-Pei Hsu and Y Wu and Yuying Hsu and Fen-Ju Hu and Guey-Jen Lee-Chen and Chiung-Mei Chen},
  journal={Dementia and geriatric cognitive disorders},
  volume={24 2},
BACKGROUND Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1alpha -889 C/T and IL-1beta -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). METHODS AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls… CONTINUE READING


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