Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy.

Abstract

In a case-control study using a clinically well-defined group of 30 multiple system atrophy (MSA) patients and 110 control subjects, homozygosity for interleukin-1A (IL-1A) allele 2 (high secretor of proinflammatory cytokine) in the regulatory region (-889) of the IL-1A gene was associated with a fivefold increased risk for MSA.

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@article{Combarros2003Interleukin1AG, title={Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy.}, author={Onofre Combarros and Jon Infante and Javier Llorca and Jos{\'e} Berciano}, journal={Movement disorders : official journal of the Movement Disorder Society}, year={2003}, volume={18 11}, pages={1385-6} }