Interleukin-19 blockade attenuates collagen-induced arthritis in rats.

@article{Hsu2012Interleukin19BA,
  title={Interleukin-19 blockade attenuates collagen-induced arthritis in rats.},
  author={Yu-Hsiang Hsu and Pei-Pei Hsieh and Ming-Shi Chang},
  journal={Rheumatology},
  year={2012},
  volume={51 3},
  pages={
          434-42
        }
}
OBJECTIVES RA is the most common form of inflammatory arthritis. IL-19 acts as a pro-inflammatory cytokine involved in the pathogenesis of RA. We investigated whether anti-IL-19 antibody treatment would modulate the severity of the disease in a CIA rat model. METHODS We generated a CIA model by immunizing rats with bovine type II collagen. CIA rats were s.c. treated with anti-IL-19 antibody 1BB1. The effects of 1BB1 on CIA rats were determined by hind-paw thickness, severity score, bone… 
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