Interleukin 18 stimulates HIV type 1 in monocytic cells.

  title={Interleukin 18 stimulates HIV type 1 in monocytic cells.},
  author={L. N. Shapiro and Adrian Puren and Hazel A. Barton and Daniela Novick and Robert L Peskind and Robert Shenkar and Yusu Gu and Michael S.-S Su and Charles A Dinarello},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 21},
The cytokine interleukin (IL) 18 (formerly interferon gamma-inducing factor) induces the T helper type 1 response. In the present studies, IL-18 increased HIV type 1 (HIV-1) production from 5- to 30-fold in the chronically infected U1 monocytic cell line. Inhibition of tumor necrosis factor (TNF) activity by the addition of TNF-binding protein reduced IL-18-stimulated HIV-1 production by 48%. In the same cultures, IL-18-induced IL-8 was inhibited by 96%. Also, a neutralizing anti-IL-6 mAb… CONTINUE READING
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