Interleukin-18 promoter -137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients.

@article{Cavalcante2020Interleukin18P,
  title={Interleukin-18 promoter -137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients.},
  author={J{\^a}nio Emanuel Andrade Cavalcante and Ederson Laurindo Holanda de Sousa and Raphael de Oliveira Rodrigues and Glautemberg de Almeida Viana and Daniel Duarte Gadelha and Manoela Montenegro Dias de Carvalho and Duaran Lopes Sousa and Allysson Jordan Xavier Silva and R. N. C. Filho and V. Fernandes and R. M. J{\'u}nior and Renata de Sousa Alves and G. C. Meneses and T. L. Sampaio and M. G. Queiroz},
  journal={Clinical biochemistry},
  year={2020}
}
BACKGROUND Interleukin-18 (IL-18), a proinflammatory and proatherogenic cytokine, has been associated with type 2 diabetes, metabolic syndrome, stroke and coronary artery disease. Some studies have indicated that the IL-18 promoter -137 G/C polymorphism seems to be associated with changes in the IL-18 expression and may contribute to the development of cardiovascular disease (CVD). The aim of this study was to evaluate the association between -137 G/C polymorphism and the levels of IL-18… Expand

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