Interleukin-18 is associated with protection against rhinovirus-induced colds and asthma exacerbations.

Abstract

Rhinoviruses cause the common cold and exacerbations of asthma. Animal models of infection have identified a protective role for interleukin-18 (IL-18). Following experimental rhinovirus infection, we observed increased respiratory symptoms in healthy and asthmatic subjects with low nasal and bronchial IL-18 levels.

DOI: 10.1093/cid/civ062

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Cite this paper

@article{Jackson2015Interleukin18IA, title={Interleukin-18 is associated with protection against rhinovirus-induced colds and asthma exacerbations.}, author={David Jeff Jackson and Nicholas Glanville and Maria-Belen Trujillo-Torralbo and Betty W. H. Shamji and Jerico del-Rosario and Patrick Mallia and Matthew J. Edwards and Ross P. Walton and Michael J. Edwards and Sebastian L Johnston}, journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America}, year={2015}, volume={60 10}, pages={1528-31} }