Interleukin-18 is associated with increased severity of atopic dermatitis in children.

@article{Sohn2004Interleukin18IA,
  title={Interleukin-18 is associated with increased severity of atopic dermatitis in children.},
  author={Myung Hyun Sohn and Kyung Eun Lee and Kyu-earn Kim},
  journal={Allergy and asthma proceedings},
  year={2004},
  volume={25 3},
  pages={181-4}
}
Atopic dermatitis (AD) is a chronic relapsing skin disease characterized by reduced interferon (IFN) gamma production with concurrent up-regulation of interleukin (IL)-4. Recently, it was reported that IL-18, formerly called IFN gamma-inducing factor, induces the production of T helper (Th)2-related cytokines without help from IL-12. This study was performed to evaluate the contribution of IL-18 in the pathogenesis of AD. Significantly higher serum IL-18 concentrations were found in patients… CONTINUE READING