Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina.

@article{Blankenberg2002Interleukin18IA,
  title={Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina.},
  author={Stefan S Blankenberg and Laurence Tiret and Christoph Hans Bickel and Dietmar Peetz and François Cambien and Juergen Meyer and Hans Jurgen Rupprecht},
  journal={Circulation},
  year={2002},
  volume={106 1},
  pages={
          24-30
        }
}
BACKGROUND Interleukin (IL)-18 plays a central role in orchestrating the cytokine cascade and accelerates atherosclerosis and plaque vulnerability in animal models. However, epidemiological data evaluating the role of IL-18 levels in atherosclerosis are lacking. METHODS AND RESULTS In a prospective study of 1229 patients with documented coronary artery disease, we measured baseline serum concentrations of IL-18 and other markers of inflammation. During the follow-up period (median, 3.9 years… CONTINUE READING

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