Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes.

@article{Chandrasekar2005Interleukin18IA,
  title={Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes.},
  author={Bysani Chandrasekar and Srinivas Mummidi and William C. Claycomb and Ruben Mestril and Mona Nemer},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 6},
  pages={4553-67}
}
In patients with congestive heart failure, high serum levels of the proinflammatory cytokine interleukin (IL)-18 were reported. A positive correlation was described between serum IL-18 levels and the disease severity. IL-18 has also been shown to induce atrial natriuretic factor (ANF) gene expression in adult cardiomyocytes. Because re-expression of the fetal gene ANF is mostly associated with hypertrophy, a hallmark of heart failure, we hypothesized that IL-18 induces cardiomyocyte hypertrophy… CONTINUE READING
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Interleukin-18 Is a Pro-hypertrophic Cytokine

  • A. T. Naito, A. Tominaga, +5 authors T. Takamatsu
  • Exp. Cell Res. 291,
  • 2003

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