Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage.

@article{Sivakumar2002Interleukin1I,
  title={Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage.},
  author={Pallavur V. Sivakumar and Gina M. Westrich and Suzanne T. Kanaly and Kirsten E Garka and Teresa L. Born and Jonathan M.J. Derry and Joanne L. Viney},
  journal={Gut},
  year={2002},
  volume={50 6},
  pages={812-20}
}
BACKGROUND AND AIMS Persistent inflammation observed in inflammatory bowel disease may be the consequence of an increased or aberrant immune response to normal gut constituents or an overall immune dysregulation and imbalance. Cytokines play an important role in immune regulation and interleukin 18 (IL-18) is one such cytokine that has emerged as being instrumental in driving CD4+ T cell responses towards a Th1-type. IL-18 can also directly mediate inflammation, moderate interleukin 1 activity… CONTINUE READING
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