Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells.

@article{Ojala2008Interleukin18IE,
  title={Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells.},
  author={Johanna O. Ojala and Elina M. Sutinen and Antero Salminen and Tuula A Pirttil{\"a}},
  journal={Journal of neuroimmunology},
  year={2008},
  volume={205 1-2},
  pages={86-93}
}
Inflammatory cytokines, produced mainly by activated microglia in the brain, can enhance neuronal degeneration and the amyloid-beta-plaque production involved in Alzheimer's disease (AD). We previously demonstrated that the expression of the pro-inflammatory cytokine interleukin-18 (IL-18) colocalizes with plaques and hyperphoshorylated tau containing… CONTINUE READING