Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency.

@article{Zorrilla2007Interleukin18CE,
  title={Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency.},
  author={Eric Zorrilla and Manuel S{\'a}nchez-Alavez and Shuei Sugama and Molly Brennan and Rosette E Fernandez and Tamas Bartfai and Bruno Conti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 26},
  pages={11097-102}
}
Circulating levels of the cytokine interleukin 18 (IL-18) are elevated in obesity. Here, we show that administration of IL-18 suppresses appetite, feed efficiency, and weight regain in food-deprived male and female C57BL/6J mice. Intraperitoneal vs. intracerebroventricular routes of IL-18 administration had similar potency and did not promote formation of a conditioned taste aversion (malaise-like behavior). Mice partially (Il18(+/-)) or totally (Il18(-/-)) deficient in IL-18 were hyperphagic… CONTINUE READING

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