• Medicine
  • Published in Cancer research 2003

Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium.

@article{Carrascal2003Interleukin18BP,
  title={Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium.},
  author={Mar{\'i}a Teresa Carrascal and Lorea Mendoza and Mar{\'i}a Valc{\'a}rcel and Clarisa Salado and Eider Egilegor and Naiara Teller{\'i}a and Fernando Vidal-Vanaclocha and Charles A Dinarello},
  journal={Cancer research},
  year={2003},
  volume={63 2},
  pages={
          491-7
        }
}
We studied the role of endogenous interleukin (IL)-18 in hepatic metastasis by blocking this cytokine using the naturally occurring IL-18 binding protein (IL-18BP). A single i.p. dose of IL-18BP given 30 min before intrasplenic injection of murine B16 melanoma (B16M) cells reduced the number of hepatic metastatic foci by 75% and metastatic volume by 80%. Same treatment reduced the intrahepatic retention of luciferase-transfected B16M by 50% and abolished VCAM-1 up-regulation in the hepatic… CONTINUE READING

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