Interleukin 18 binding protein ameliorates ischemia/reperfusion-induced hepatic injury in mice.

@article{Ouzounidis2016Interleukin1B,
  title={Interleukin 18 binding protein ameliorates ischemia/reperfusion-induced hepatic injury in mice.},
  author={Nikolaos Ouzounidis and Alexandros E Giakoustidis and T Poutahidis and Katerina Angelopoulou and Stavros Iliadis and Antonis Chatzigiagkos and Argyro Zacharioudaki and Stamatis Angelopoulos and Apostolos E Papalois and Vasilios Papanikolaou and Dimitrios Giakoustidis},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  year={2016},
  volume={22 2},
  pages={237-46}
}
Inflammation-associated oxidative stress contributes to hepatic ischemia/reperfusion injury (IRI). Detrimental inflammatory event cascades largely depend on activated Kupffer cells (KCs) and neutrophils, as well as proinflammatory cytokines, including tumor necrosis factor α (TNF-α) and interleukin (IL) 18. The aim of our study was to evaluate the effects of IL 18 binding protein (IL 18Bp) in hepatic IRI of mice. Thirty C57BL/6 mice were allocated into 3 groups: sham operation, ischemia… CONTINUE READING
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