Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.

  title={Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.},
  author={Daniela Novick and Sung Hyun Kim and Giamila Fantuzzi and Leonid L. Reznikov and Charles A Dinarello and Menachem Rubinstein},
  volume={10 1},
An interleukin-18 binding protein (IL-18BP) was purified from urine by chromatography on IL-18 beads, sequenced, cloned, and expressed in COS7 cells. IL-18BP abolished IL-18 induction of interferon-gamma (IFNgamma), IL-8, and activation of NF-kappaB in vitro. Administration of IL-18BP to mice abrogated circulating IFNgamma following LPS. Thus, IL-18BP functions as an inhibitor of the early Th1 cytokine response. IL-18BP is constitutively expressed in the spleen, belongs to the immunoglobulin… CONTINUE READING
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