Interleukin-18 and interleukin-12 synergistically inhibit osteoclastic bone-resorbing activity.

  title={Interleukin-18 and interleukin-12 synergistically inhibit osteoclastic bone-resorbing activity.},
  author={Naoko Yamada and Satomi Niwa and Tohru Tsujimura and Teruo Iwasaki and Ayako Sugihara and Hiroyuki Futani and Shinya Hayashi and Haruki Okamura and Hitoshi Akedo and Nobuyuki Terada},
  volume={30 6},
The effect of interleukin (IL)-18 on osteoclastic bone-resorbing activity was investigated in vitro. Osteoclast-enriched cells, about 70% of which were tartrate-resistant acid phosphatase (TRAP)-positive, were cultured on dentine slices, and then the total volume of resorption pits on each dentine slice was measured as bone-resorbing activity. When the effects of IL-18 alone at 1, 10, 100, and 1000 ng/mL were examined, bone-resorbing activity was significantly reduced only at 1000 ng/mL, by… CONTINUE READING
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