Interleukin-18 Is Critical for Mucosa-Associated Invariant T Cell Gamma Interferon Responses to Francisella Species In Vitro but Not In Vivo.

@article{Jesteadt2018Interleukin18IC,
  title={Interleukin-18 Is Critical for Mucosa-Associated Invariant T Cell Gamma Interferon Responses to Francisella Species In Vitro but Not In Vivo.},
  author={Eric Jesteadt and Irma Zhang and Huifeng Yu and Anda I. Meierovics and Wei-Jen Chua Yankelevich and Siobh{\'a}n C Cowley},
  journal={Infection and immunity},
  year={2018},
  volume={86 5}
}
Mucosa-associated invariant T (MAIT) cells are a subset of innate T cells that express a semi-invariant Vα chain paired with limited Vβ chains. MAIT cells are activated by riboflavin metabolite derivatives presented by the nonpolymorphic major histocompatibility complex class I (MHC-I)-like molecule MR1. The precise mechanisms required to activate MAIT cells are an area of intense interest. Here we used two closely related intracellular pathogens with distinct inflammasome activation phenotypes… CONTINUE READING