Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

@article{Udagawa1997Interleukin18F,
  title={Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation},
  author={Nobuyuki Udagawa and Nicole J. Horwood and Jan Elliott and Alan Mackay and Jane Owens and Haruki Okamura and Masashi Kurimoto and Timothy John Chambers and T. John Martin and Matthew T. Gillespie},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={185},
  pages={1005 - 1012}
}
We have established by differential display polymerase chain reaction of mRNA that interleukin (IL)-18 is expressed by osteoblastic stromal cells. The stromal cell populations used for comparison differed in their ability to promote osteoclast-like multinucleated cell (OCL) formation. mRNA for IL-18 was found to be expressed in greater abundance in lines that were unable to support OCL formation than in supportive cells. Recombinant IL-18 was found to inhibit OCL formation in cocultures of… CONTINUE READING
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