Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis.

@article{Yuan2007Interleukin18AP,
  title={Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis.},
  author={Bosi Yuan and R M Zhu and Martin Braddock and Xiu-feng Zhang and Wei Shi and Ming-Hua Zheng},
  journal={Expert opinion on therapeutic targets},
  year={2007},
  volume={11 10},
  pages={1261-71}
}
A large body of clinical and experimental evidence suggests that cytokines play a key role in the pathogenesis of local and systemic complications of acute pancreatitis. IL-18 is a pro-inflammatory cytokine that plays a key role in many human diseases, including acute pancreatitis. This review focuses on the present understanding in IL-18 and its potential role in acute pancreatitis. IL-18 levels reflect the severity of acute pancreatitis and display a significant negative correlation with the… CONTINUE READING