Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells.

@article{Zijlstra2011Interleukin17AIG,
  title={Interleukin-17A induces glucocorticoid insensitivity in human bronchial epithelial cells.},
  author={Gavin Zijlstra and Nick H. T. ten Hacken and Roland F. Hoffmann and Antoon J. M. van Oosterhout and Irene H Heijink},
  journal={The European respiratory journal},
  year={2011},
  volume={39 2},
  pages={
          439-45
        }
}
A subset of asthma patients suffer from glucocorticoid (GC) insensitivity. T-helper cell type 17 cells have an emerging role in GC insensitivity, although the mechanisms are still poorly understood. We investigated whether interleukin (IL)-17A induces GC insensitivity in airway epithelium by studying its effects on responsiveness of tumour necrosis factor (TNF)-α-induced IL-8 production to budesonide in human bronchial epithelial 16HBE cells. We unravelled the underlying mechanism by the use of… CONTINUE READING
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