Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance.

@article{Acharya2017Interleukin17APC,
  title={Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance.},
  author={Dhiraj Acharya and Penghua Wang and Amber M Paul and Jianfeng Dai and David Gate and Jordan E Lowery and Dobrivoje S. Stokic and Arturo A. Leis and Richard A Flavell and Terrence C. Town and Erol Fikrig and Fengwei Bai},
  journal={Journal of virology},
  year={2017},
  volume={91 1}
}
CD8+ T cells are crucial components of immunity and play a vital role in recovery from West Nile virus (WNV) infection. Here, we identify a previously unrecognized function of interleukin-17A (IL-17A) in inducing cytotoxic-mediator gene expression and promoting CD8+ T cell cytotoxicity against WNV infection in mice. We find that IL-17A-deficient (Il17a-/-) mice are more susceptible to WNV infection and develop a higher viral burden than wild-type (WT) mice. Interestingly, the CD8+ T cells… CONTINUE READING