Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro.

BACKGROUND Interleukin 17 (IL17) is produced by activated T cells and has been implicated in the development of bone lesions and cartilage degradation in rheumatoid arthritis (RA). OBJECTIVE To determine whether IL17, alone or together with tumour necrosis factor alpha (TNFalpha), induces cartilage destruction in vitro. METHODS Fetal mouse metatarsals… CONTINUE READING