Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.

@article{Meng2012Interleukin17SI,
  title={Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.},
  author={Fanli Meng and Kundong Wang and Tomonori Aoyama and Sergei I. Grivennikov and Yonghan Paik and David Scholten and M M Zhang Cong and Keiko Iwaisako and Xiao Lin Liu and Mingjun Zhang and Christoph H. {\"O}sterreicher and Felix Stickel and Klaus Ley and David Allen Brenner and Tatiana Kisseleva},
  journal={Gastroenterology},
  year={2012},
  volume={143 3},
  pages={
          765-776.e3
        }
}
BACKGROUND & AIMS Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis. We examined the role of IL-17 signaling in the pathogenesis of liver fibrosis in mice. METHODS Using cholestatic and hepatotoxic models of liver injury, we compared the development of liver fibrosis in wild-type mice with that of IL-17RA(-/-) mice and of bone marrow chimeric mice devoid of IL-17 signaling in immune and Kupffer cells (IL-17RA(-/-) to wild-type and IL-17A(-/-) to wild-type mice) or… CONTINUE READING
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