Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes.

@article{Qiu2009Interleukin17RC,
  title={Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes.},
  author={Zheng Qiu and Chris Dillen and Jialiang Hu and Hannelien Verbeke and Sofie Struyf and Jo Van Damme and Ghislain Opdenakker},
  journal={Immunobiology},
  year={2009},
  volume={214 9-10},
  pages={835-42}
}
Interleukin 17 (IL-17) is a proinflammatory cytokine, produced only by activated lymphocytes, but with a broad cellular host range. The effects of IL-17 on fibroblasts were investigated by analysis of the induction of chemokine and matrix metalloprotease (MMP) mRNA levels by RT-PCR. IL-17 stimulated CC chemokine (monocyte chemotactic protein-1; MCP-1/JE) and CXC (KC, MIP-2) chemokine and TIMP-1 mRNA expression in fibroblastoid L929 cells. In normal mouse embryonic fibroblasts (MEF) this… CONTINUE READING

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