Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.

@article{Tzartos2008Interleukin17PI,
  title={Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.},
  author={John S. Tzartos and Manuel A Friese and Matthew J. Craner and Jackie Palace and Jia Newcombe and Margaret M. Esiri and Lars Fugger},
  journal={The American journal of pathology},
  year={2008},
  volume={172 1},
  pages={146-55}
}
Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis, implicate a novel CD4+ T-cell subset (TH17), characterized by the secretion of interleukin-17 (IL-17), in disease pathogenesis. To elucidate its role in MS, brain tissues from patients with MS were compared to controls. We detected expression of IL-17 mRNA (by in situ hybridization) and protein (by immunohistochemistry) in perivascular lymphocytes as well as in astrocytes and… CONTINUE READING
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