Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
@article{Tzartos2008Interleukin17PI, title={Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.}, author={John Tzartos and Manuel A. Friese and Matthew J. Craner and Jackie Palace and Jia Newcombe and Margaret M. Esiri and Lars Fugger}, journal={The American journal of pathology}, year={2008}, volume={172 1}, pages={ 146-55 } }
Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis, implicate a novel CD4+ T-cell subset (TH17), characterized by the secretion of interleukin-17 (IL-17), in disease pathogenesis. To elucidate its role in MS, brain tissues from patients with MS were compared to controls. We detected expression of IL-17 mRNA (by in situ hybridization) and protein (by immunohistochemistry) in perivascular lymphocytes as well as in astrocytes and…
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